Tricyclic Antidepressants (TCA): Norpamin (desipramine)
TCAs are a class of drugs used for treating depression. TCAs are the older antidepressants. TCAs have a very low lethal dose. Since patients taking TCAs have a higher likelihood of suicidal tendencies, TCAs are often implicated in overdose situations. New antidepressant drugs like Prozac, Paxil, Zoloft are NOT TCAs and, as such, will not cross react on the TCA assay.
Drug Class
Depressant/Sedative/Hypnotic
Trade Names
Elavil (amitriptyline), Aventyl (nortriptyline), Tofranil (imipramine), Norpamin (desipramine), Sinquan (doxepin)
Street Names
None
Effects Of Use
Increased heart rate, drowsiness, dry mouth, constipation, urinary retention, blurred vision, dizziness, confusion, and sexual dysfunction.
Approximate Detection Time
Urine: up to 10 days

Oral Fluid: NA
Urine Cutoff Levels
Immunoassay (screening): 1000 ng/mL

GC/MS (confirmation): 1000 ng/mL. TCAs cannot be analyzed by GC/MS very well, so they are often confirmed by HPLC or another method
Primary Antigen
Nortriptyline
Common Cross-Reactants
Large doses of carbamazepine (Tegretol) metabolites, other prescription drugs may also cross react.


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